The KL2 Career Development Awards Program at Washington University in St. Louis provides high-quality, multidisciplinary training in clinical and translational research to promote the career development of future clinical investigators. This program provides financial support and benefits that allow scholars to focus on mentored, multidisciplinary research, supplemented by applicable coursework.
Victoria J. Fraser, MD
Jane Garbutt, MBChB
75% of a KL2 Scholar's salary (up to $75,000 per year) is provided by the program. Surgeons may request a lower level of effort, but not less than 50%.
A minimum of 75% protected time must be guaranteed by each KL2 scholar’s department. Surgeons may only be allowed 50% protected research time.
Up to $25,000 per year in research funds and support for travel are provided to each scholar annually.
Tuition is provided for graduate-level coursework, including but not limited to: the Certificate in Clinical Investigation, the Master of Science in Clinical Investigation (MSCI), or the Master of Population Health Sciences (MPHS)
Participation in the Clinical Research Training Center (CRTC) KL2 Career Development Program may count toward the requirements of the NIH Loan Repayment Program (LRP). Visit the LRP website for more information: http://www.lrp.nih.gov/about_the_programs/clinical.aspx
KL2 scholars are provided with limited funding for travel in order to attend the required annual Translational Science National Meeting.
KL2 scholars have access to the Clinical Research Training Center. The CRTC provides computer labs, break-out rooms, classroom, poster printing, and administrative office suites.
Continuation in the KL2 Career Development Awards Program is determined yearly based upon satisfactory research progress, professional effort, academic grades, and attendance and participation in CRTC events.
KL2 Scholars are expected to devote 75% of their full-time effort to the training and clinical research activities of the KL2 program unless other terms have been negotiated prior to matriculation into the program.
Scholars’ remaining effort may be devoted to other clinical or academic pursuits consistent with the award. NIH policy requires that the remainder of a scholar’s salary (the portion NOT paid by the KL2 program) must come from non-federal sources.
Developing a sucessful clinical and translational research career requires strong relationships with mentors and a research team. Each scholar must have program-approved primary and secondary mentors. The primary mentor will be the scholar’s main source of research supervision and career development. Scholars are expected to meet with their mentors monthly. KL2 mentors are expected to be available for consultation and support concerning the scholar’s current projects and future progress. KL2 mentors are also expected to provide formal feedback to the scholar at least annually.
KL2 scholars are required to enroll in the following:
Scholars are required to attend the weekly MTPCI Seminar (currently held on Tuesday afternoons) during the Fall and Spring semesters (mid-August through May). Scholars are required to present research-in-progress once each year. Feedback will be provided from the Directors, Mentors, and Peers in attendance.
One session each month will be dedicated to Career Development topics. During these seminars, external speakers will be invited to present.
KL2 scholars must establish a Career Development Plan in consultation with their mentors and advisory committee. This plan must be submitted annually in September.
All Career Development Plans should include:
The Washington University School of Medicine hosts the Research Training Symposium and Poster Session annually in October. All KL2 scholars are required to submit an abstract and present a poster at the Symposium each year of their appointments. Scholars are given the option to have their research considered for an oral presentation.
KL2 Scholars are required to attend the annual Retreat hosted by the CRTC. During this late-afternoon event, speakers will be highlighting topics relevant to Scholars’ Career Development and Research.
Scholars are required to provide to the Program current IRB approvals for their research project(s).
Scholars are required to complete the course Ethical and Legal Issues in Clinical Research (M17-510) during their time in the program as part of their training in the Responsible Conduct of Research. Scholars must also comply with Responsible Conduct of Research (RCR) Guidelines (See http://grants.nih.gov/grants/guide/notice-files/not-od-10-019.html) for the duration of the program.
All presentations and publications related to research funded by the Postdoctoral MTPCI must cite the appropriate grant award. Citation Guidelines are available at: [link]
Scholars are to keep the Program informed of their individual progress including published manuscripts, abstracts, submitted grant applications and awards in a timely manner. Additionally, at least once each year, all Scholars are required to provide progress report detailing their research-in-progress.
Scholars are required to submit a budget to the CRTC Financial Coordinator prior to the start of their program appointment and each subsequent year of the program. This budget must outline projected expenses to be covered by research funds. Budget revisions and expense reports are required as incurred. All scholars are expected to follow the financial policies of the Program. Failure to follow Program policies may result in denial of reimbursement or purchase requests.
Scholars are required to schedule an appointment with the RDBG and their mentors to discuss their research plan and specific needs at the start of each program year. The purpose of the RDBG is to provide Scholars with guidance on data management and statistical analysis.
Each year a meeting of all national clinical and translational research programs is hosted. This meeting presents an exceptional opportunity to meet and interact with key clinical research leaders from the NIH, to hear and read about multidisciplinary clinical research at other CTSA-awarded institutions, to network with scholars and leaders from across the nation, and to form collaborative partnerships in multidisciplinary clinical research. Scholars are required to attend and present their research at this meeting held in Washington D.C. in their first year of the program. Travel expenses will be paid for KL2 scholars to meet this program requirement.
Scholars are expected to complete required program evaluations twice per year. These evaluations are administered online and are mandatory for all scholars.
KL2 scholars must possess a doctoral-level degree. This includes, but is not limited to: MD, PhD, Pharm D, DrPH, DO, DDS, PsyD, DOT, DPT, DC, DSN, or DNSc as well as biostatisticians, epidemiologists, behavioral scientists, and nurses with doctoral degrees.
Eligible applicants must be citizens or non-citizen nationals of the United States, or have been lawfully admitted to the United States for permanent residence and have in their possession an Alien Registration Receipt Card (I-151 or I-551) or other legal verification of admission for permanent residence. Non-citizen nationals are persons born in lands that are not States but are under U.S. sovereignty, jurisdiction, or administration (e.g., American Samoa). Individuals on visas are not eligible.
Individuals applying to the KL2 Program should be at an early stage of their career, even while they are in subspecialty training. The KL2 Program expects applicants to be postdoctoral level trainees or early junior faculty level trainees who plan to conduct, or are conducting, clinical research.
The KL2 award is not intended for individuals making mid-career changes into clinical research.
All KL2 scholars must be able to devote 75% professional effort to the program for a minimum of two years (surgeons may request a lower level of effort, but not less than 50%).
All applicants must be conducting clinical, translational research. Clinical research is defined as patient-oriented research, that is, research conducted with human subjects or on material of human origin such as tissues, specimens and cognitive phenomena, for which an investigator or colleague directly interacts with human subjects.
KL2 scholars must have the support of two mentors. These mentors must be approved by the Program and must come from two different disciplines.
Applicants may NOT have served as Principal Investigator on an NIH R01, K series, or subproject of a P or M series grant prior to candidacy
Applicants may not obtain salary support from other federal grants until the final two years of mentored K support (NOT-OD-08-065). Applicants may not obtain support if previously supported on a K award beyond 5 years.
If a potential scholar is already studying under an existing K12, he/she is still eligible for the KL2 program. However, the cumulative length of time under NIH-sponsored K programs should be no more than 5 years. The minimum amount of time any one Scholar may spend in this Trans-NIH KL2 program is two years, KL2 applicants may not have had more than three years of support under the previous K12 program. Furthermore, the KL2 applicant would need to justify the need for additional mentored research training or training in a team context as it is not advised for one’s career development to transfer from another Institutional K-Award to the KL2 Program.
Individuals who are or have been a Principal Investigator on mentored career development grants (e.g., K-series) or with substantial independent funding (e.g., R01, P01, P50) or other equivalent research grant awards are ineligible.
The KL2 Career Development Program strongly encourages applicants from outside the School of Medicine, including individuals outside WU, SLU, STLCOP, UMSL and SIUE.
KL2 Scholars may not simultaneously participate in clinical fellowships leading to clinical certification.
Career Development Program funds cannot be used to support clinical fellowship training. However, fellows who have completed the part of their fellowship needed for sub specialty certification are eligible to apply. For example, although a Medical Oncology fellowship may last 3-4 years, fellows who have completed 2 years may be eligible to sit for the boards, and are therefore eligible.
Please read the following prior to filling out an application:
Each applicant is required to submit a current NIH Biosketch and Other Support documents.
Applicant must submit a 3-5 page career development plan (no more than 5 pages; references are not included in page count) that includes, but is not limited to, the following:
The required Research Plan should follow the standard NIH format (PHS 398).
The Research Plan includes:
|Section of Research Plan||Page Limit|
|Introduction (Resubmission Only)||1 page|
|Specific Aims & Research Strategy (Significance, Innovation, and Approach)||5 pages|
|Protection of Human Subjects, Inclusion of Women and Minorities, Inclusion of Children, Vertebrate Animals||3 pages|
|Targeted/Planned Enrollment Table||1 page|
|Bibliography and References Cited/Progress Report Publication List (include PMCID # if applicable) and Consortium/Contractual Arrangements||No page limit|
Applicants are required to submit a current NIH Biosketch, Other Support document, and Trainee Table for both the Primary and Secondary mentors proposed on the KL2 application.
Mentoring is a critical part of the KL2 Career Development Awards, and who your mentors are is very important. The KL2 application requires two mentors from different disciplines. Applicants must identify one mentor as primary and one as secondary. Applicants must establish a relationship with the proposed mentor prior to submission of the KL2 Career Development application. Please do not select a mentor without prior approval of the mentor.
Each applicant’s Department Chair or Division Chief is required to submit a letter of support describing the applicant’s potential and guaranteeing the protected time (75%) required for participation in the KL2 Career Development Program. This letter of support must be uploaded by the application deadline (September 16). Upon submission of the online application form, an email will be automatically generated to the identified Department Chair or Division Chief with guidelines and instructions regarding how to upload the required letter. It is the responsibility of the applicant to verify that the identified reference has received the email. The online application site provides applicants with a checklist on which they may view confirmation of the documents that have been uploaded to their application.
Letters of Recommendation must:
The last document uploaded will be the document reviewed. It is important for the Department Chair to understand that their letters must include a signature and be on official letterhead. The link sent to each Department Chair is unique for each applicant, and one link cannot be used to upload documents for multiple applicants.
Each applicant’s is required to have 2 letters of recommendation submitted by references in addition to the Department Chair. These letters should describe the applicant’s potential to succeed as an independent researcher. All letters of recommendation must be uploaded by the application deadline. Upon submission of the online application form, an email will be automatically generated to the identified references with guidelines and instructions regarding how to upload the required letter. It is the responsibility of the applicant to verify that the identified reference has received the email. The online application site provides applicants with a checklist on which they may view confirmation of the documents that have been uploaded to their application.
Letters of Recommendation must:
The last document uploaded will be the document reviewed. It is important for references to understand that their letters must include a signature and be on official letterhead. The link sent to each Reference is unique for each applicant, and one link cannot be used to upload documents for multiple applicants.
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